Pair Name	Alpha-Hederin, Carboplatin
Disease Info	[ICD-11: 2B90.Z]	Colon cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Phosphorylation	PIK3CA	hsa5290
	Up-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Phosphorylation	MAPK8	hsa5599
	Up-regulation	Expression	CASP3	hsa836
	Down-regulation	Expression	CCND1	hsa595
In Vivo Model	The running experiment was designed to test the chemopreventive activity of α-hederin when used as an adjuvant to carboplatin in an experimental model of mouse colon hyperplasia induced by 1,2-dimethylhydrazine (DMH). Fifty male Swiss albino mice were classified into five groups: group (I): saline group, group (II): DMH-induced colon hyperplasia control group, group (III): DMH + carboplatin (5 mg/kg) group, group (IV): DMH + α-hederin (80 mg/kg) group, and group (V): DMH + carboplatin (5 mg/kg)+α-hederin (80 mg/kg) group.
Result	Chemopreventive effect of α-hederin/carboplatin combination against experimental colon hyperplasia and impact on JNK signaling